Cathepsin - mediated necrosis controls the adaptive immune response by Th 2 - associated adjuvants * Running title : Necrosis controls adaptive immunity

نویسندگان

  • Lee S. Jacobson
  • Heriberto Lima
  • Michael F. Goldberg
  • Vasilena Gocheva
  • Vladislav Tsiperson
  • Fayyaz S. Sutterwala
  • Johanna A. Joyce
  • Bianca V. Gapp
  • Vincent A. Blomen
  • Kartik Chandran
  • Thijn R. Brummelkamp
  • Felipe Diaz-Griffero
  • Jürgen Brojatsch
چکیده

* This work was supported in part by the US National Institutes of Health grants (1R56AI092497-01A1 to J.B., 5R01CA125162-05 to J.A.J., 5R01AI087630-02 to F.S.S., and 5R01AI088027-02 to K.C), and by the Martin Turkish and the M-O’Connor-Foundation. 1 To whom correspondence should be addressed: Dept. of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. Tel: 718-430 3079; E-mail: [email protected]. 2 The abbreviations used are: LLOMe, L-leucyl-L-leucine methyl ester; NLR, nucleotidebinding domain and leucine rich repeat-containing; OVA, ovalbumin; PI, propidium iodide. _________________________________________________________________________________________

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تاریخ انتشار 2012